The School of Medicine consists of the Faculty of Medicine and the Faculty of Health Sciences. The Kusunoki Campus-based Faculty of Medicine emerged from the re-organization of the Prefectural Technical College of Medicine established in 1944, which subsequently became the Hyogo Prefectural College of Medicine (1946), and the Kobe Prefectural College of Medicine (1952).

Faculty of Medicine provides students with opportunities to acquire knowledge of medical ethics as well as basic clinical and medical techniques, while encouraging them to be competent, conscientious medical doctors. Lectures are given by facultymembers of the Graduate School of Medicine.

The Myodani Campus-based Faculty of Health Sciences emerged from the School of Nursing attached to the Hyogo Prefectural College of Medicine, which was originally established in 1959. Lectures are given by faculty members of the Graduate School of Health Sciences.